人类综合征性肥胖的分子生理学

Molecular physiology of syndromic obesities in humans.

作者信息

Chung Wendy K, Leibel Rudolph L

机构信息

Division of Molecular Genetics and the Naomi Berrie Diabetes Center, Columbia University Medical College, Russell Berrie Medical Science Pavilion, Room 620, 1150 St Nicholas Avenue, New York, NY 10032, USA.

出版信息

Trends Endocrinol Metab. 2005 Aug;16(6):267-72. doi: 10.1016/j.tem.2005.06.009.

DOI:10.1016/j.tem.2005.06.009

PMID:16005242

Abstract

Obesity has become an increasingly prevalent public health problem and represents the complex interaction of genetic, developmental, behavioral and environmental influences. Although rare, the study of syndromic forms of obesity provides insight into underlying molecular and physiological mechanisms by which adiposity is regulated through food intake, energy expenditure and partitioning of stored calories.

摘要

肥胖已成为一个日益普遍的公共卫生问题，它代表了遗传、发育、行为和环境因素的复杂相互作用。尽管肥胖综合征的形式较为罕见，但对其进行研究有助于深入了解潜在的分子和生理机制，通过这些机制，肥胖可通过食物摄入、能量消耗和储存热量的分配得到调节。