Pape L, Ehrich J H H, Zivicnjak M, Offner G
Department of Paediatric Nephrology, Medical School of Hannover, Carl-Neuberg Strasse 1, D-30625 Hannover, Germany.
Lancet. 2005;366(9480):151-3. doi: 10.1016/S0140-6736(05)66872-9.
The extent to which growth after renal transplantation differs between children with a living related donor graft (LRD) and those with a cadaveric donor graft (CAD) is unclear. We retrospectively studied growth in the 5 years after transplantation in 30 boys who received LRD and 21 who received CAD. Height was similar in both groups after transplantation but was greater in LRD than in CAD recipients during follow-up. LRD recipients were taller at all ages, and had greater growth velocity in infancy and during puberty. Glomerular filtration rate (GFR) was higher immediately after transplantation in LRD than in CAD recipients, but did not differ between the groups during follow-up. GFR and other factors did not affect height 5 years after transplantation. These findings support use of LRD as the preferred option in children.
活体亲属供肾移植（LRD）儿童与尸体供肾移植（CAD）儿童肾移植后的生长差异程度尚不清楚。我们回顾性研究了30例接受LRD的男孩和21例接受CAD的男孩移植后5年的生长情况。移植后两组身高相似，但随访期间LRD组高于CAD组。LRD受者在各年龄段均更高，在婴儿期和青春期生长速度更快。LRD组移植后即刻的肾小球滤过率（GFR）高于CAD组，但随访期间两组无差异。移植后5年GFR和其他因素不影响身高。这些发现支持将LRD作为儿童的首选方案。
