血清胱抑素C水平作为肾功能受损的潜在良好标志物。

Serum cystatin C level as a potentially good marker for impaired kidney function.

作者信息

Uzun Hafize, Ozmen Keles Melek, Ataman Rezzan, Aydin Seval, Kalender Betül, Uslu Ezel, Simsek Gönül, Halac Metin, Kaya Safiye

机构信息

Department of Biochemistry, Cerrahpasa Medicine Faculty, Istanbul University, Cerrahpasa Tip Fakültesi, Temel Bilimler-Biokimya Anabilim Dali, 34303 Cerrahpasa-Istanbul, Turkey.

出版信息

Clin Biochem. 2005 Sep;38(9):792-8. doi: 10.1016/j.clinbiochem.2005.05.012.

DOI:10.1016/j.clinbiochem.2005.05.012

PMID:16005452

Abstract

OBJECTIVES

To evaluate the diagnostic significance of serum cystatin C levels in clinical practice.

DESIGN AND METHODS

Serum (99m)Tc-DTPA clearance was compared with serum cystatin C, creatinine, beta(2)-microglobulin levels and creatinine clearance in a group of patients aged 42.61 +/- 7.55 years with glomerular filtration rates of 10-60 mL/min/1.73 m(2) (n = 52) and healthy controls aged 43.90 +/- 12.06 years (n = 52).

RESULTS

No effect of sex on serum cystatin C levels was observed, but average levels increased with age. No significant difference was evident between the mean cystatin C levels of three blood samples taken at 1 month intervals from healthy subjects. Reference clearance was correlated with creatinine clearance (r = 0.957), cystatin C (r = 0.828), beta(2)-microglobulin (r = 0.767) and creatinine (r = 0.682). 60 mL/min/1.73 m(2) was chosen as the borderline for receiver-operating characteristics analysis. The values for the cut-off point, sensitivity, specificity and the area under curve were determined for cystatin C as 1.36 mg/L, 98%, 99% and 0.99 +/- 00.1, respectively; for creatinine, the values were 103 micromol/L, 80%, 100% and 0.97 +/- 0.01, respectively, and for beta(2)-microglobulin, the values were 2.51 mg/L, 86%, 92% and 0.94 +/- 0.02, respectively.

CONCLUSION

Serum cystatin C level can be used as a marker for renal damage.

摘要

目的

评估血清胱抑素C水平在临床实践中的诊断意义。

设计与方法

比较了一组年龄为42.61±7.55岁、肾小球滤过率为10 - 60 mL/min/1.73 m²（n = 52）的患者与年龄为43.90±12.06岁的健康对照者（n = 52）的血清（99m）Tc - DTPA清除率、血清胱抑素C、肌酐、β2 - 微球蛋白水平及肌酐清除率。

结果

未观察到性别对血清胱抑素C水平有影响，但平均水平随年龄增长而升高。从健康受试者每隔1个月采集的三份血样的平均胱抑素C水平之间无显著差异。参考清除率与肌酐清除率（r = 0.957）、胱抑素C（r = 0.828）、β2 - 微球蛋白（r = 0.767）和肌酐（r = 0.682）相关。选择60 mL/min/1.73 m²作为受试者工作特征分析的临界值。胱抑素C的截断点、敏感性、特异性和曲线下面积值分别确定为1.36 mg/L、98%、99%和0.99±0.01；肌酐的相应值分别为103 μmol/L、80%、100%和0.97±0.01，β2 - 微球蛋白的相应值分别为2.51 mg/L、86%、92%和0.94±0.02。