Department of Internal Medicine, Polykliniki General Hospital, 10552 Athens, Greece.
Cardiol Res Pract. 2010 Oct 14;2011:163281. doi: 10.4061/2011/163281.
Background. The aim of the present study was to examine sources of variation for serum cystatin C in a healthy Greek population. Methods. Cystatin C together with basic clinical chemistry tests was measured in a total of 490 adults (46 ± 16 yrs, 40% males) who underwent an annual health check. Demographic, anthropometric, and lifestyle characteristics were recorded. Results. Higher values of cystatin C were observed among males (P = .04), participants aged over 65 years (P < .001), current smokers (P = .001) and overweight/obese participants (P = .03). On the contrary, alcohol consumption and physical activity seemed to have no influence on cystatin C levels (P = .61; P = .95, resp.). Conclusions. In interpreting serum cystatin C values in a healthy adult population, age, gender, Body Mass Index, and cigarette smoking need to be considered, and determination of reference ranges among distinct subpopulations seem to be prudent.
背景。本研究的目的是在健康的希腊人群中检测胱抑素 C 血清的变异来源。
方法。共对 490 名成年人（46±16 岁，40%为男性）进行了年度健康检查，检测了胱抑素 C 与基本临床化学测试。记录了人口统计学、人体测量学和生活方式特征。
结果。男性（P=0.04）、年龄超过 65 岁的参与者（P<0.001）、当前吸烟者（P=0.001）和超重/肥胖参与者（P=0.03）的胱抑素 C 值较高。相反，饮酒和体育活动似乎对胱抑素 C 水平没有影响（P=0.61；P=0.95）。
结论。在解释健康成年人群的血清胱抑素 C 值时，需要考虑年龄、性别、体重指数和吸烟状况，并在不同亚人群中确定参考范围似乎是谨慎的。
