Vinod K Yaragudri, Hungund Basalingappa L
Division of Analytical Psychopharmacology, New York State Psychiatric Institute, New York, USA.
Life Sci. 2005 Aug 19;77(14):1569-83. doi: 10.1016/j.lfs.2005.05.041.
Several natural lipids have emerged as candidate modulators of central nervous system (CNS) functions. Fatty acid amides and their coupled signaling pathways are known to regulate several physiological and behavioral processes. Recent studies from our laboratory and others also have implicated endogenous marijuana-like brain constituents, endocannabinoids (ECs), and cannabinoid-1 (CB1) receptors in the neural circuitry that mediate drug addiction and neuropsychiatric disorders. Neuroadaptation to chronic ethanol (EtOH) has been shown to involve changes in the EC system. These changes include alterations in the synthesis of EC, their precursors, as well as density and coupling efficacy of CB1 receptors. The evidence for the participation of the EC system in the pathophysiology of various neuropsychiatric disorders is just beginning to evolve. It is of great interest to explore the components of EC system in different areas of the CNS for further understanding of its role in health and disease. This article presents a comprehensive overview of the currently available literature pertaining to the role of the EC system in alcoholism, schizophrenia, depression and/or suicide.
几种天然脂质已成为中枢神经系统（CNS）功能的候选调节因子。已知脂肪酸酰胺及其相关信号通路可调节多种生理和行为过程。我们实验室及其他机构最近的研究还表明，内源性大麻素样脑成分、内源性大麻素（ECs）和大麻素-1（CB1）受体参与了介导药物成瘾和神经精神疾病的神经回路。对慢性乙醇（EtOH）的神经适应性变化已表明涉及EC系统的改变。这些变化包括EC及其前体合成的改变，以及CB1受体的密度和偶联效率的改变。EC系统参与各种神经精神疾病病理生理学的证据才刚刚开始显现。探索中枢神经系统不同区域的EC系统组成部分，以进一步了解其在健康和疾病中的作用，具有极大的意义。本文全面概述了目前关于EC系统在酒精中毒、精神分裂症、抑郁症和/或自杀中作用的现有文献。
