Griffith Nathan M, Szaflarski Jerzy P, Szaflarski Magdalena, Kent Glenn P, Schefft Bruce K, Howe Steven R, Privitera Michael D
Department of Psychology, University of Cincinnati, Cincinnati, OH, USA.
Epilepsy Behav. 2005 Sep;7(2):266-72. doi: 10.1016/j.yebeh.2005.05.004.
Major depressive disorder (MDD) is the most prevalent psychiatric comorbidity among patients with treatment-resistant seizures. The Beck Depression Inventory-II (BDI-II) is often used to measure the severity of self-reported depressive symptoms among patients with seizure disorders. In contrast, researchers often use the Profile of Mood States (POMS) Depression (D) scale to assess depressed mood among other medical patient groups. The clinical significance of POMS-D scores among seizure disorder patients is not clear. In this study, we computed the correlation of POMS-D and BDI-II scores, determined a formula for converting POMS-D scores to BDI-II scores, and computed the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the POMS-D among seizure disorder patients. Two BDI-II cutoffs (BDI-II16 and 20) were used as criteria for significant reported depressive symptoms. We found a strong correlation between POMS-D and BDI-II scores. Analyses indicated that POMS-D scores strongly predict BDI-II scores. In addition, the sensitivity, specificity, PPV, and NPV values obtained demonstrated that POMS-D scores accurately classify seizure disorder patients who endorse significant depressive symptoms. These results suggest that the POMS-D may be effective in measuring reported depressive symptoms among seizure disorder patients.
重度抑郁症（MDD）是难治性癫痫患者中最常见的精神科合并症。贝克抑郁量表第二版（BDI-II）常被用于测量癫痫患者自我报告的抑郁症状严重程度。相比之下，研究人员常使用情绪状态剖面图（POMS）抑郁（D）量表来评估其他内科患者群体的抑郁情绪。癫痫患者中POMS-D分数的临床意义尚不清楚。在本研究中，我们计算了POMS-D与BDI-II分数的相关性，确定了将POMS-D分数转换为BDI-II分数的公式，并计算了癫痫患者中POMS-D的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）。使用两个BDI-II临界值（BDI-II 16和20）作为报告有显著抑郁症状的标准。我们发现POMS-D与BDI-II分数之间存在很强的相关性。分析表明，POMS-D分数能有力地预测BDI-II分数。此外，所获得的敏感性、特异性、PPV和NPV值表明，POMS-D分数能准确地对认可有显著抑郁症状的癫痫患者进行分类。这些结果表明，POMS-D可能在测量癫痫患者报告的抑郁症状方面有效。
