Gulaboglu Mine, Yildiz Leyla, Celebi Fehmi, Gul Mustafa, Peker Kemal
Department of Biochemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey.
Clin Chem Lab Med. 2005;43(6):581-4. doi: 10.1515/CCLM.2005.101.
It has been suggested that iodine plays an important role in gastric cancer. Gastric cancer ranks first among the cancers in the north-eastern Anatolia region, Turkey, where iodine deficiency is common. In this study, iodine levels were determined in gastric cancer and surrounding normal tissues in 19 patients with gastric cancer. Tissue iodine levels were determined by the Foss method based on the Sandell-Kolt-hoff reaction. Tissue iodine levels were lower in gastric cancer tissue (17.8+/-3.4 ng I/mg protein, mean+/-SEM) compared with surrounding normal tissue (41.7+/-8.0 ng I/mg protein) (p<0.001). There was positive correlation between the iodine levels in gastric cancer tissue and surrounding normal tissue (r = 0.845, p<0.001). There was no significant difference in iodine levels in cancer and surrounding normal tissue between male and female subjects. The iodine deficiency in our region may be one of the factors for increased gastric cancer prevalence. Our results support the hypothesis that iodine plays an important role in gastric cancer development.
有人提出碘在胃癌中起重要作用。在土耳其安纳托利亚东北部地区，胃癌在各类癌症中位居首位，而该地区碘缺乏情况普遍。在本研究中，对19例胃癌患者的癌组织及周围正常组织中的碘含量进行了测定。采用基于桑德尔-科尔特霍夫反应的福斯方法测定组织碘含量。与周围正常组织（41.7±8.0 ng I/毫克蛋白质）相比，胃癌组织中的组织碘含量较低（17.8±3.4 ng I/毫克蛋白质）（p<0.001）。胃癌组织与周围正常组织中的碘含量呈正相关（r = 0.845，p<0.001）。男性和女性受试者的癌组织及周围正常组织中的碘含量无显著差异。我们地区的碘缺乏可能是胃癌患病率增加的因素之一。我们的结果支持碘在胃癌发生中起重要作用这一假说。
