Kharitonov Sergey V
Department of Analytical Chemistry, Saint-Petersburg State Institute of Technology, Moskovsky pr. 26, Saint-Petersburg 190013, Russian Federation.
Anal Bioanal Chem. 2005 Aug;382(7):1642-51. doi: 10.1007/s00216-005-3351-9. Epub 2005 Jul 9.
The construction and electroanalytical response characteristics of poly(vinyl chloride) matrix ion-selective sensors (ISSs) for drotaverine hydrochloride are described. The membranes incorporate ion-association complexes of drotaverine with tetraphenylborate, picrate, tetraiodomercurate, tetraiodobismuthate, Reinecke salt, and heteropolycompounds of Keggin structure-molybdophosphoric acid, tungstophosphoric acid, molybdosiliconic acid and tungstosiliconic acid as electroactive materials for ionometric sensor controls. These ISSs have a linear response to drotaverine hydrochloride over the range 8 x 10(-6) to 5 x 10(-2) mol L(-1) with cationic slopes from 51 to 58 mV per concentration decade. These ISSs have a fast response time (up to 1 min), a low determination limit (down to 4.3 x 10(-6) mol L(-1)), good stability (3-5 weeks), and reasonable selectivity. Permeabilities and ion fluxes through a membrane were calculated for major and interfering ions. Dependences of the transport properties of the membranes on the concentrations of the ion exchanger and near-membrane solution and their electrochemical characteristics are presented. The ISSs were used for direct potentiometry and potentiometric titration (sodium tetraphenylborate) of drotaverine hydrochloride. Results with mean accuracy of 99.1+/-1.0% of nominal were obtained which corresponded well to data obtained by use of high-performance liquid chromatography.
描述了用于盐酸屈他维林的聚氯乙烯基质离子选择性传感器（ISSs）的构建及其电分析响应特性。这些膜包含屈他维林与四苯基硼酸盐、苦味酸盐、四碘汞酸盐、四碘铋酸盐、雷氏盐以及具有Keggin结构的杂多化合物（钼磷酸、钨磷酸、钼硅酸和钨硅酸）的离子缔合物，作为离子计传感器控制的电活性材料。这些离子选择性传感器对盐酸屈他维林在8×10⁻⁶至5×10⁻² mol L⁻¹范围内具有线性响应，阳离子斜率为每浓度十年51至58 mV。这些离子选择性传感器具有快速响应时间（长达1分钟）、低测定限（低至4.3×10⁻⁶ mol L⁻¹）、良好的稳定性（3 - 5周）和合理的选择性。计算了主要离子和干扰离子通过膜的渗透率和离子通量。给出了膜的传输性质对离子交换剂和近膜溶液浓度及其电化学特性的依赖性。这些离子选择性传感器用于盐酸屈他维林的直接电位法和电位滴定法（四苯基硼酸钠）。获得的结果平均准确度为标称值的99.1±1.0%，与使用高效液相色谱法获得的数据吻合良好。
