Maifeld Sarah V, Lee Daesung
Department of Chemistry, University of Wisconsin, Madison, 53706, USA.
Chemistry. 2005 Oct 21;11(21):6118-26. doi: 10.1002/chem.200500407.
The ring-closing metathesis (RCM) of dienynes represents a powerful methodology for the construction of mono- and bicyclic systems containing 1,3-diene functionality. Despite its synthetic potential, the utility of dienyne RCM is significantly reduced due to poor group selectivity. To circumvent this shortcoming, several strategies utilizing steric hindrance, electronic variation, relay metathesis and ring-closure kinetics have been implemented to exert control over the reaction pathways. This article highlights a variety of methods to achieve group-selective enyne RCM of dienynes.
二烯炔的关环复分解反应（RCM）是构建含有1,3 - 二烯官能团的单环和双环体系的一种强大方法。尽管具有合成潜力，但由于基团选择性较差，二烯炔RCM的实用性显著降低。为了克服这一缺点，已经实施了几种利用空间位阻、电子变化、接力复分解反应和关环动力学的策略来控制反应途径。本文重点介绍了实现二烯炔的基团选择性烯炔RCM的多种方法。
