Kim Yi Jin, Lee Daesung
Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA.
Org Lett. 2006 Nov 9;8(23):5219-22. doi: 10.1021/ol061952y.
[Structure: see text] A tandem ring-closing metathesis (RCM) of silaketal-tethered dienynes gives rise to bicyclic siloxanes, which upon removal of the silicon tether afford dienediol skeletons with a stereodefined E,Z-1,3-diene motif. The implementation of this methodology has led to the construction of the entire C1-C21 linear carbon skeleton of tartrolon B.
[结构：见正文] 硅缩酮连接的二烯炔的串联闭环复分解反应（RCM）生成双环硅氧烷，去除硅连接基后得到具有立体定义的E，Z-1,3-二烯基序的二烯二醇骨架。该方法的实施导致了 tartrolon B的整个C1-C21线性碳骨架的构建。
