Zhang Li-qiang, Yao Wan-zhen, He Quan-ying, Wang Yu-zhu, Ren Bin, Lin Ya-ping
Department of Respiration, Third Hospital of Peking University, Beijing 100083, China.
Zhonghua Nei Ke Za Zhi. 2005 May;44(5):333-6.
To investigate the association of polymorphisms in the beta(2) and beta(3) adrenergic receptor (beta(2)-ADR and beta(3)-ADR) genes with obstructive sleep apnea/hypopnea syndrome (OSAHS).
The genotypes and alleles of beta(2)-ADR and beta(3)-ADR genes were identified by polymerase chain reaction-restricted fragment length polymorphism assay in 318 unrelated subjects of North region Han population of China (including 165 male OSAHS subjects and 153 male non-OSAHS subjects). The genotypes and allele frequencies of the polymorphisms were compared between OSAHS group and non-OSAHS group. The effects of the polymorphisms in OSAHS group on body mass index (BMI), neck circumference (NC), waist/hip rate (WHR), apnea-hypopnea index (AHI), systolic blood pressure (SBP), diastolic blood pressure (DBP) were analyzed.
There were significant differences in genotypes distribution in beta(3)-ADR polymorphism between the two groups (chi(2) = 10.434, P = 0.006). Compared with the control group, OSAHS group had significantly higher Arg allele frequency in beta(3)-ADR polymorphism (chi(2) = 12.742, P = 0.004). There were independent effects of beta(3)-ADR polymorphism on BMI, NC, WHR in OSAHS group; carriers of the Arg allele of beta(3)-ADR polymorphism had greater BMI, NC, and WHR (P = 0.019, 0.025, 0.012), while the carriers of the Arg allele had greater AHI and SBP (P = 0.032, 0.035), but after adjusted for BMI, AHI and age, there were no differences in SBP between the carriers and non-carriers of Arg allele (P = 0.097). There were no significant differences in the genotypes and allele frequencies in beta(2)-ADR polymorphism between the two groups (chi(2) = 1.406 and 0.809, P = 0.465 and 0.382).
beta(3)-ADR polymorphism may be involved in the development of central obesity and may be related to OSAHS by the central obesity in male OSAHS subjects of North region Han population of China, and may be induce hypertension in OSAHS patients of the population indirectly through obesity and sleep apnea. On the contrary, beta(2)-ADR polymorphism may not be correlated with central obesity and OSAHS in the population.
探讨β₂和β₃肾上腺素能受体（β₂-ADR和β₃-ADR）基因多态性与阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的关系。
采用聚合酶链反应-限制性片段长度多态性分析法，对318名中国北方地区汉族无关受试者（包括165名男性OSAHS患者和153名男性非OSAHS患者）的β₂-ADR和β₃-ADR基因的基因型和等位基因进行鉴定。比较OSAHS组和非OSAHS组多态性的基因型和等位基因频率。分析OSAHS组多态性对体重指数（BMI）、颈围（NC）、腰臀比（WHR）、呼吸暂停低通气指数（AHI）、收缩压（SBP）、舒张压（DBP）的影响。
两组间β₃-ADR多态性的基因型分布存在显著差异（χ² = 10.434，P = 0.006）。与对照组相比，OSAHS组β₃-ADR多态性的Arg等位基因频率显著更高（χ² = 12.742，P = 0.004）。β₃-ADR多态性对OSAHS组的BMI、NC、WHR有独立影响；β₃-ADR多态性的Arg等位基因携带者的BMI、NC和WHR更大（P = 0.019、0.025、0.012），而Arg等位基因携带者的AHI和SBP更大（P = 0.032、0.035），但在调整BMI、AHI和年龄后，Arg等位基因携带者和非携带者的SBP无差异（P = 0.097）。两组间β₂-ADR多态性的基因型和等位基因频率无显著差异（χ² = 1.406和0.809，P = 0.465和0.382）。
β₃-ADR多态性可能参与了中心性肥胖的发生发展，在中国北方地区汉族男性OSAHS患者中可能通过中心性肥胖与OSAHS相关，并可能通过肥胖和睡眠呼吸暂停间接诱发该人群OSAHS患者的高血压。相反，β₂-ADR多态性可能与该人群的中心性肥胖和OSAHS无关。
