Eynon Elizabeth E, Zenewicz Lauren A, Flavell Richard A
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Cell. 2005 Jul 15;122(1):2-4. doi: 10.1016/j.cell.2005.06.035.
The human gut is host to hundreds of different species of commensal bacteria that live in peaceful partnership with the host immune system. These commensal bacteria are far from neutral bystanders as they are intimately involved in the development of the immune system. Reporting in this issue of Cell, Kasper and colleagues (Mazmanian et al., 2005) reveal that a bacterial polysaccharide, PSA, produced by the commensal bacterium Bacteroides fragilis directs development of the immune system of the mouse host.
人类肠道是数百种不同共生细菌的宿主，这些细菌与宿主免疫系统建立了和平共处的伙伴关系。这些共生细菌绝非中立的旁观者，因为它们密切参与了免疫系统的发育过程。在本期《细胞》杂志上发表报告的卡斯珀及其同事（马兹马尼亚等人，2005年）揭示，共生细菌脆弱拟杆菌产生的一种细菌多糖PSA能够引导小鼠宿主免疫系统的发育。
