Mazmanian Sarkis K, Kasper Dennis L
Division of Biology, California Institute of Technology, Mail code 156-29, 1200 East California Boulevard, Pasadena, California 91125, USA.
Nat Rev Immunol. 2006 Nov;6(11):849-58. doi: 10.1038/nri1956. Epub 2006 Oct 6.
This article explores the fascinating relationship between the mammalian immune system and the bacteria that are present in the mammalian gut. Every human is an ecosystem that hosts 10(13)-10(14) bacteria. We review the evidence that immunomodulatory molecules produced by commensal bacteria in the gut have a beneficial influence on the development of certain immune responses, through eliciting the clonal expansion of CD4(+) T-cell populations. This process seems to contribute to the overall health of the host by offering protection against various diseases and might provide supporting evidence at a molecular level for the 'hygiene hypothesis' of allergic immune disorders.
本文探讨了哺乳动物免疫系统与哺乳动物肠道内细菌之间的迷人关系。每个人都是一个容纳10¹³ - 10¹⁴个细菌的生态系统。我们回顾了相关证据，即肠道内共生细菌产生的免疫调节分子通过引发CD4⁺ T细胞群体的克隆扩增，对某些免疫反应的发展产生有益影响。这一过程似乎通过提供针对各种疾病的保护作用，有助于宿主的整体健康，并且可能在分子水平上为过敏性免疫疾病的“卫生假说”提供支持证据。
