Chen Tzy-Yen, Hsieh Yih-Shou, Yang Chi-Chieh, Wang Chi-Ping, Yang Shun-Fa, Cheng Yan-Wen, Chiou Hui-Ling
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC.
Clin Biochem. 2005 Jul;38(7):632-8. doi: 10.1016/j.clinbiochem.2005.03.005.
A direct relationship between cystatin C levels and the severity of hepatic disease has been revealed in our previous study. This study was aimed to consider whether a correlation exists between matrix metalloproteinases (MMPs), which have been proven to be involved in liver cirrhosis, and cystatin C to reflect the severity of hepatic disease.
A total of 154 consecutive patients with various liver diseases were recruited to determine their serum levels of cystatin C, MMP-2 and-9, together with other hepatic parameters. These were compared with 40 normal controls.
Average levels of MMP-2 and cystatin C were significantly higher in patients while MMP-9 was significantly lower, as compared to controls. A linear regression analysis has revealed a direct relationship between cystatin C and MMP-2 (Y=83.39 + 270.56 X, R=0.38, P< 0.001), as well as between MMP-2 and the severity of liver diseases.
This is the first study to demonstrate a correlation between cystatin C and MMP-2, suggesting that there may be certain interactions between cystatin C and MMP-2 in patients with hepatic diseases.
我们之前的研究已揭示胱抑素C水平与肝脏疾病严重程度之间存在直接关系。本研究旨在探讨已被证实参与肝硬化的基质金属蛋白酶（MMPs）与胱抑素C之间是否存在相关性，以反映肝脏疾病的严重程度。
共纳入154例连续的各种肝脏疾病患者，测定其血清胱抑素C、MMP-2和-9水平以及其他肝脏参数。将这些结果与40例正常对照进行比较。
与对照组相比，患者的MMP-2和胱抑素C平均水平显著升高，而MMP-9显著降低。线性回归分析显示胱抑素C与MMP-2之间存在直接关系（Y = 83.39 + 270.56X，R = 0.38，P < 0.001），以及MMP-2与肝脏疾病严重程度之间存在直接关系。
这是第一项证明胱抑素C与MMP-2之间存在相关性的研究，表明在肝脏疾病患者中胱抑素C与MMP-2之间可能存在某些相互作用。
