Takahashi Katsuhiko, Mukaida Tetsunori, Goto Tetsuya, Oka Chikahiro
Hiroshima HART Clinic, Nakaku, Hiroshima, Japan.
Fertil Steril. 2005 Jul;84(1):88-92. doi: 10.1016/j.fertnstert.2004.12.051.
To evaluate perinatal outcome of ultrarapid vitrified blastocyst transfer.
Retrospective study.
Private IVF clinics.
PATIENT(S): One hundred eight women, who delivered 147 babies.
INTERVENTION(S): Supernumerary blastocysts were vitrified using cryoloop method and transferred after warming.
MAIN OUTCOME MEASURE(S): Survival rate of blastocyst after vitrification, implantation and pregnancy rates, neonatal outcome and congenital birth defects.
RESULT(S): A total of 1,129 vitrified blastocysts from 435 cycles were warmed and 967 survived (85.7%). In 413 cycles of transfer, the pregnancy, implantation, and abortion rates were 44.1%, 29.0%, and 22.0%, respectively. Of 108 deliveries, 34 (32.9%) were multiple pregnancies and 20 were preterm (18.5%). Out of 147 children born, 50.3% were male and congenital birth defects were observed in 1.4%. These results were similar with those of fresh blastocyst transfer program.
CONCLUSION(S): The vitrification of blastocyst using cryoloop is a simple, easy, and quick method. This technique yields the same high pregnancy and implantation rates as fresh blastocyst transfer. Congenital defect rate in this study was similar to fresh blastocyst transfer, proving the method to be safe.
评估超快速玻璃化囊胚移植的围产期结局。
回顾性研究。
私立体外受精诊所。
108名妇女，分娩147名婴儿。
使用冷冻环法将多余的囊胚玻璃化，并在复温后进行移植。
玻璃化后囊胚的存活率、着床率和妊娠率、新生儿结局及先天性出生缺陷。
435个周期中总共1129个玻璃化囊胚复温，967个存活（85.7%）。在413个移植周期中，妊娠率、着床率和流产率分别为44.1%、29.0%和22.0%。108例分娩中，34例（32.9%）为多胎妊娠，20例早产（18.5%）。147名出生儿童中，50.3%为男性，先天性出生缺陷发生率为1.4%。这些结果与新鲜囊胚移植项目的结果相似。
使用冷冻环进行囊胚玻璃化是一种简单、易行且快速的方法。该技术产生的妊娠率和着床率与新鲜囊胚移植相同。本研究中的先天性缺陷率与新鲜囊胚移植相似，证明该方法是安全的。
