Higher aneuploidy rates of chromosomes 13, 16, and 21 in a patient with globozoospermia.

OBJECTIVE

To analyze rates of chromosomal anomalies in a patient with globozoospermia.

DESIGN

Case report.

SETTING

Tertiary-care infertility clinic.

PATIENT(S): A 44-year-old man with 100% globozoospermia.

INTERVENTION(S): Fixation of sperms and analysis of aneuploidies and diploidies by fluorescence in situ hybridization.

MAIN OUTCOME MEASURE(S): Aneuploidy rates of chromosomes 13, 16, and 21 and diploidy rate in a patient with 100% globozoospermia.

RESULT(S): The aneuploidy rates in spermatozoa from a patient with globozoospermia were significantly higher than in a normospermic man. The incidence of a disomy of the chromosomes 13, 16, and 21 was 4%, 5%, and 1%, respectively, and the nullisomy rates were 2%, 2%, and 3%, respectively.

CONCLUSION(S): This study demonstrates a positive correlation between globozoospermia and higher chromosomal aneuploidies of the chromosomes 13, 16, and 21, suggesting a higher risk of creating aneuploid embryos after intracytoplasmic sperm injection treatment for globozoospermia patients.