Andersson H, Mobacken H
Department of Clinical Nutrition, University of Göteborg, Sahlgrenska Hospital, Gothenburg, Sweden.
Eur J Clin Nutr. 1992 May;46(5):309-15.
Essentially all patients with dermatitis herpetiformis (DH) and dermal granular IgA deposits have a gluten-sensitive enteropathy as seen in coeliac disease. A gluten-free diet would normally restore mucosal morphology within months. The dapsone medication required to suppress the skin lesions could be gradually reduced and/or finally discontinued in most patients if they constantly adhere to the diet. The immunological reactions may also be reduced. The gluten-free diet could thus be successful both concerning manifestations from the skin and the gut. Although well known in dermatological literature, diet therapy in DH has attracted little interest in journals of nutrition. A survey of this causal diet therapy for the disease therefore seems appropriate.
基本上,所有患有疱疹样皮炎(DH)且真皮有颗粒状IgA沉积的患者都患有与乳糜泻类似的麸质敏感性肠病。无麸质饮食通常会在数月内恢复黏膜形态。如果大多数患者持续坚持这种饮食,那么抑制皮肤病变所需的氨苯砜药物剂量可以逐渐减少和/或最终停用。免疫反应也可能会降低。因此,无麸质饮食在改善皮肤和肠道症状方面可能会取得成功。尽管在皮肤病学文献中广为人知,但DH的饮食疗法在营养期刊上却很少受到关注。因此,对这种针对该疾病的病因性饮食疗法进行调查似乎是合适的。