转录偶联修复与早衰。

Transcription-coupled repair and premature ageing.

作者信息

Andressoo J O, Hoeijmakers J H J

机构信息

MGC Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus Medical Center, P.O. Box 1738, 3000DR Rotterdam, The Netherlands.

出版信息

Mutat Res. 2005 Sep 4;577(1-2):179-94. doi: 10.1016/j.mrfmmm.2005.04.004.

DOI:10.1016/j.mrfmmm.2005.04.004

PMID:16009385

Abstract

During the past decades, several cellular pathways have been discovered to be connected with the ageing process. These pathways, which either suppress or enhance the ageing process, include regulation of the insulin/growth hormone axis, pathways involved with caloric restriction, ROS metabolism and DNA repair. In this review, we will provide a comprehensive overview of cancer and/or accelerated ageing pathologies associated with defects in the multi-step nucleotide excision repair pathway. Moreover, we will discuss evidence suggesting that there is a causative link between transcription-coupled repair and ageing.

摘要

在过去几十年中，人们发现了几条与衰老过程相关的细胞通路。这些通路，无论是抑制还是加速衰老过程，都包括胰岛素/生长激素轴的调节、与热量限制有关的通路、活性氧代谢和DNA修复。在这篇综述中，我们将全面概述与多步骤核苷酸切除修复通路缺陷相关的癌症和/或加速衰老病理。此外，我们将讨论表明转录偶联修复与衰老之间存在因果关系的证据。