Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA,
Adv Exp Med Biol. 2013;767:17-46. doi: 10.1007/978-1-4614-5037-5_2.
Superfamily I is a large and diverse group of monomeric and dimeric helicases defined by a set of conserved sequence motifs. Members of this class are involved in essential processes in both DNA and RNA metabolism in all organisms. In addition to conserved amino acid sequences, they also share a common structure containing two RecA-like motifs involved in ATP binding and hydrolysis and nucleic acid binding and unwinding. Unwinding is facilitated by a "pin" structure which serves to split the incoming duplex. This activity has been measured using both ensemble and single-molecule conditions. SF1 helicase activity is modulated through interactions with other proteins.
超家族 I 是一个由一组保守序列基序定义的大型且多样化的单体和二聚体解旋酶家族。该类别的成员参与所有生物体中 DNA 和 RNA 代谢的基本过程。除了保守的氨基酸序列外，它们还具有共同的结构，包含两个 RecA 样结构域，参与 ATP 结合和水解以及核酸结合和解旋。解旋是通过“销”结构来辅助的，该结构用于分裂进入的双链。已经使用整体和单分子条件来测量 SF1 解旋酶的活性。SF1 解旋酶的活性通过与其他蛋白质的相互作用来调节。
