Gill S S, Lewis R P, Reilly C S
Department of Anaesthesia, University of Sheffield, United Kingdom.
Eur J Anaesthesiol. 1992 May;9(3):203-7.
Forty-four patients, ASA Grade I or II, had anaesthesia induced with propofol at 100 mg min-1 followed by a maintenance rate of 6 mg kg-1 h-1 or a stepdown regimen of 10 mg kg-1 h-1 for 10 min, 8 mg kg-1 h-1 for the next 10 min and at 6 mg kg-1 h-1 thereafter. Anaesthesia was maintained with propofol infused using an Ohmeda 9000 pump supplemented by nitrous oxide and oxygen (2:1) in a Bain circuit with spontaneous ventilation. Incremental doses of 20 mg of propofol were given to both groups as clinically indicated to maintain anaesthesia. Both methods provided satisfactory maintenance of anaesthesia but significantly more incremental doses were required in the group receiving the steady rate infusion. However, a lower cumulative dose was required up to 30 min in this group but not by 40 min. A comparable fall in systolic and diastolic blood pressure and heart rate was seen in both groups. There was no difference in the recovery times between the groups and the total dose did not correlate with time to recovery.
44例美国麻醉医师协会（ASA）分级为I或II级的患者，首先以100mg/min的速度静脉注射丙泊酚诱导麻醉，随后分别采用6mg·kg⁻¹·h⁻¹的维持速度或先以10mg·kg⁻¹·h⁻¹的速度输注10分钟、再以8mg·kg⁻¹·h⁻¹的速度输注接下来的10分钟、之后以6mg·kg⁻¹·h⁻¹的速度输注的递减方案。采用Ohmeda 9000注射泵输注丙泊酚维持麻醉，并在Bain回路中以笑气和氧气（2:1）辅助，患者自主呼吸。两组均根据临床需要给予20mg递增剂量的丙泊酚以维持麻醉。两种方法均能满意地维持麻醉，但持续恒速输注组所需的递增剂量明显更多。然而，该组在30分钟内所需的累积剂量较低，但40分钟时则不然。两组患者的收缩压、舒张压和心率下降幅度相当。两组患者的苏醒时间无差异，且总剂量与苏醒时间无关。
