James M F, Beer R E, Esser J D
Department of Anaesthesia, Hillbrow Hospital, South Africa.
Anesth Analg. 1989 Jun;68(6):772-6.
The effects of pre-treatment with 60 mg/kg body weight magnesium sulfate intravenous on cardiovascular responses and catecholamine release associated with tracheal intubation were measured in 15 normal patients and in 15 saline solution pre-treated controls. Magnesium pre-treatment increased heart rate by 13 +/- 3.9 beats/minute. After intubation, heart rate was unchanged in the magnesium group at 107.3 +/- 3.6 beats/minute but increased in the control group to 120.9 +/- 4.6 beats/minute (P less than 0.05). Systolic blood pressure increased after intubation from 106.8 +/- 3.1 to 121.0 +/- 4.4 mm Hg in patients given magnesium and from 106.4 +/- 3.12 to 145.1 +/- 5.6 mm Hg in the control group (P less than 0.05). Norepinephrine levels increased from 297.3 +/- 20.9 pg/ml to a peak of 532.5 +/- 30.1 pg/ml 2 minutes after intubation in the magnesium group. In controls, norepinephrine levels increased from 273.3 +/- 39.1 mg/ml to 944.6 +/- 68.7 pg/ml (P less than 0.05 for differences between groups). Epinephrine levels were unchanged from baseline after magnesium but in controls increased from 113.9 +/- 19.5 to 279.6 +/- 92.3 pg/ml (P less than 0.05). We conclude that magnesium sulfate attenuates the catecholamine mediated responses after tracheal intubation.
在15名正常患者和15名接受生理盐水预处理的对照组中，测量了静脉注射60mg/kg体重硫酸镁预处理对与气管插管相关的心血管反应和儿茶酚胺释放的影响。镁预处理使心率增加13±3.9次/分钟。插管后，镁组心率保持不变，为107.3±3.6次/分钟，而对照组心率增加至120.9±4.6次/分钟（P<0.05）。接受镁治疗的患者插管后收缩压从106.8±3.1mmHg升高至121.0±4.4mmHg，对照组从106.4±3.12mmHg升高至145.1±5.6mmHg（P<0.05）。镁组去甲肾上腺素水平在插管后2分钟从297.3±20.9pg/ml升高至峰值532.5±30.1pg/ml。在对照组中，去甲肾上腺素水平从273.3±39.1mg/ml升高至944.6±68.7pg/ml（组间差异P<0.05）。镁治疗后肾上腺素水平与基线相比无变化，但对照组从113.9±19.5升高至279.6±92.3pg/ml（P<0.05）。我们得出结论，硫酸镁可减轻气管插管后儿茶酚胺介导的反应。
