Senninger N
Department of Surgery, University of Heidelberg, FRG.
Eur Surg Res. 1992;24 Suppl 1:68-73. doi: 10.1159/000129241.
The main bile-induced pancreatitis models are described with special attention to the duct injection models in dogs and the obstruction/reflux model in opossums. Practical problems of setup, study controls and monitoring are addressed. As for the opossum model, due to its clinical relevance the high variability of problems in the pathogenesis of pancreatitis that may be tackled by this model makes it a very useful, simple and not too expensive tool in the hands of a pancreatitis researcher.
本文描述了主要的胆汁诱导性胰腺炎模型，特别关注犬类的导管注射模型和负鼠的梗阻/反流模型。文中还讨论了模型建立、研究对照和监测方面的实际问题。至于负鼠模型，鉴于其临床相关性，该模型可解决胰腺炎发病机制中存在的高度变异性问题，使其成为胰腺炎研究人员手中一种非常有用、简单且成本不高的工具。
