非氨酯可减轻体内缺氧缺血性脑损伤。

Felbamate reduces hypoxic-ischemic brain damage in vivo.

作者信息

Wasterlain C G, Adams L M, Hattori H, Schwartz P H

机构信息

Epilepsy Research Laboratory, VA Medical Center, Sepulveda, CA 91343.

出版信息

Eur J Pharmacol. 1992 Mar 3;212(2-3):275-8. doi: 10.1016/0014-2999(92)90343-3.

DOI:10.1016/0014-2999(92)90343-3

PMID:1601070

Abstract

The neuroprotective effects of felbamate were tested in a model of incomplete cerebral ischemia and hypoxia in 7-day-old rat pups. Felbamate pretreatment (300 mg/kg) reduced the surface of infarcted cortex following bilateral carotid ligation, by 42-49% compared to saline and dimethylsulfoxide (DMSO) controls, respectively. The number of necrotic neurons in the dentate gyrus was reduced by 77% over both DMSO controls and saline controls. These results suggest that felbamate deserves further evaluation for its therapeutic potential in hypoxia-ischemia.

摘要

在7日龄大鼠幼崽的不完全性脑缺血缺氧模型中测试了非氨酯的神经保护作用。非氨酯预处理（300mg/kg）在双侧颈动脉结扎后，与生理盐水和二甲基亚砜（DMSO）对照组相比，分别使梗死皮层面积减少了42%-49%。与DMSO对照组和生理盐水对照组相比，齿状回中坏死神经元的数量减少了77%。这些结果表明，非氨酯在缺氧缺血方面的治疗潜力值得进一步评估。