Chronopoulos A, Stafstrom C, Thurber S, Hyde P, Mikati M, Holmes G L
Department of Neurology, Harvard Medical School, Boston, Massachusetts.
Epilepsia. 1993 Mar-Apr;34(2):359-66. doi: 10.1111/j.1528-1157.1993.tb02422.x.
Felbamate (FBM), a newly developed antiepileptic drug (AED), was previously shown to offer some neuroprotective effects against hypoxic injury in both in vivo and in vitro studies. We administered FBM (100 or 300 mg/kg) to 30-day-old rats 1 h after they received a convulsant dosage of kainic acid (KA). Animals were then tested at age 80 days in the water maze, open field, and handling tests. Seizure latency was then tested by flurothyl inhalation. Animals that received 300 mg/kg FBM performed better in all three tests and had longer latencies to flurothyl-induced seizures than did animals that received vehicle. This study suggests that FBM may have some neuroprotective effects after KA-induced status epilepticus (SE).
非氨酯（FBM）是一种新开发的抗癫痫药物（AED），先前的体内和体外研究均表明它对缺氧损伤具有一定的神经保护作用。我们在30日龄大鼠接受惊厥剂量的海藻酸（KA）1小时后，给它们施用非氨酯（100或300mg/kg）。然后在80日龄时对动物进行水迷宫、旷场和处理测试。接着通过吸入三氟乙烷测试癫痫发作潜伏期。接受300mg/kg非氨酯的动物在所有三项测试中表现更好，并且与接受赋形剂的动物相比，对三氟乙烷诱导的癫痫发作具有更长的潜伏期。这项研究表明，非氨酯在KA诱导的癫痫持续状态（SE）后可能具有一定的神经保护作用。
