5-羟色胺受体在右芬氟拉明对大鼠进食模式影响中的作用。

Role of 5-HT receptors in the effect of d-fenfluramine on feeding patterns in the rat.

作者信息

Grignaschi G, Samanin R

机构信息

Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

出版信息

Eur J Pharmacol. 1992 Mar 3;212(2-3):287-9. doi: 10.1016/0014-2999(92)90346-6.

DOI:10.1016/0014-2999(92)90346-6

PMID:1601071

Abstract

The effect of d-fenfluramine, 1.5 mg/kg i.p., on meal patterns was studied in rats treated i.p. with 1 mg/kg metergoline or 0.5 mg/kg ritanserin or s.c. with 3 mg/kg (+/-)cyanopindolol. d-Fenfluramine significantly reduced eating rate, meal size and total intake in the first 4 h of testing and the effects were antagonized by metergoline. (+/-)Cyanopindolol reduced total intake and the effect of d-fenfluramine on this measure; the effect of d-fenfluramine on meal size (but not on eating rate) was also reduced by (+/-)cyanopindolol. Ritanserin only reduced the rate of eating and the effect of d-fenfluramine on this measure. The results suggest that 5-HT1 receptors, possibly of the 5-HT1B type, are involved in the ability of d-fenfluramine to cause satiety in freely feeding rats.

摘要

研究了腹腔注射1.5毫克/千克右旋芬氟拉明对经腹腔注射1毫克/千克美替拉酮、0.5毫克/千克利坦色林或皮下注射3毫克/千克（±）氰吲哚洛尔处理的大鼠进食模式的影响。右旋芬氟拉明显著降低了测试前4小时的进食速率、进食量和总摄入量，且这些作用可被美替拉酮拮抗。（±）氰吲哚洛尔降低了总摄入量以及右旋芬氟拉明对此指标的影响；（±）氰吲哚洛尔还降低了右旋芬氟拉明对进食量（但不影响进食速率）的作用。利坦色林仅降低了进食速率以及右旋芬氟拉明对此指标的影响。结果表明，5-羟色胺1受体（可能是5-羟色胺1B型）参与了右旋芬氟拉明使自由进食大鼠产生饱腹感的能力。