Vickers S P, Clifton P G, Dourish C T
Laboratory of Experimental Psychology, University of Sussex, Brighton, UK.
Psychopharmacology (Berl). 1996 May;125(2):168-75. doi: 10.1007/BF02249416.
These studies investigated the involvement of the 5-HT1A receptor in mediating d-fenfluramine-induced anorexia in the rat. Non-deprived, d-fenfluramine-treated (3.0 mg/kg) rats consumed a reduced amount of a palatable wet mash and showed a temporal advance in the behavioural sequence consistent with satiety. Thus, rats treated with d-fenfluramine ceased feeding and began resting before corresponding controls. Pretreatment with the selective 5-HT1A receptor antagonist WAY-100,635 (1.0 mg/kg) had no effect on either the reduced mash consumption or behavioural satiety sequence of d-fenfluramine-treated animals at a dose which was found to attenuate the anorexia induced by the 5-HT1A receptor agonist 8-OH-DPAT (0.5 mg/kg). Pretreatment with the non-selective 5-HT antagonist metergoline (1.0 mg/kg) attenuated the d-fenfluramine-induced reduction of mash consumption and the advanced offset of feeding. Metergoline pretreatment had no effect on the advanced onset of resting observed in d-fenfluramine-treated animals. These data suggest that d-fenfluramine reduces food intake, perhaps by enhancing satiety, via a mechanism which does not involve the 5-HT1A receptor subtype. The implications of these results to the utility of the behavioural satiety sequence as a measure of postprandial satiety are discussed.
这些研究调查了5-羟色胺1A（5-HT1A）受体在介导右旋芬氟拉明引起的大鼠厌食症中的作用。未禁食、经右旋芬氟拉明处理（3.0毫克/千克）的大鼠食用的可口湿饲料量减少，并且在与饱腹感一致的行为序列中出现时间提前。因此，经右旋芬氟拉明处理的大鼠在相应对照组之前停止进食并开始休息。用选择性5-HT1A受体拮抗剂WAY-100,635（1.0毫克/千克）预处理，对右旋芬氟拉明处理动物的饲料消耗量减少或行为饱腹感序列均无影响，该剂量已被发现可减轻5-HT1A受体激动剂8-羟基二丙胺甲苯（8-OH-DPAT，0.5毫克/千克）引起的厌食症。用非选择性5-HT拮抗剂美替拉酮（1.0毫克/千克）预处理可减轻右旋芬氟拉明引起的饲料消耗量减少和进食提前结束。美替拉酮预处理对右旋芬氟拉明处理动物中观察到的休息提前开始没有影响。这些数据表明，右旋芬氟拉明可能通过增强饱腹感来减少食物摄入量，其机制不涉及5-HT1A受体亚型。讨论了这些结果对将行为饱腹感序列用作餐后饱腹感测量方法的实用性的影响。
