巴布亚新几内亚的亚急性硬化性全脑炎（SSPE）：幼儿中的高发病率。
Subacute sclerosing panencephalitis (SSPE) in Papua New Guinea: a high incidence in young children.
作者信息
Lucas K M, Sanders R C, Rongap A, Rongap T, Pinai S, Alpers M P
机构信息
Department of Microbiology, La Trobe University, Bundoora, Australia.
出版信息
Epidemiol Infect. 1992 Jun;108(3):547-53. doi: 10.1017/s0950268800050044.
Eighty-seven cases of subacute sclerosing panencephalitis (SSPE) were diagnosed from September 1988 to April 1991 in Papua New Guinea (PNG), by demonstration of high-titre measles-specific antibodies in cerebrospinal fluid (CSF). For 1990 the annual incidence of SSPE, for the study provinces, was calculated to be 56 cases per million under 20 years of age and it is expected that this figure will be higher in 1991. The mean age of presentation was 4.9 years, with a male to female ratio of 1.8:1. An elevation in the ratio of immunoglobulin G as a percentage of total protein in CSF and an increase in the CSF:serum immunoglobulin G ratio was shown in SSPE patients. The dramatic appearance and high frequency of the disease in PNG might relate to the early age of measles infection encountered in children in this country.
1988年9月至1991年4月期间，在巴布亚新几内亚（PNG），通过检测脑脊液（CSF）中高滴度的麻疹特异性抗体，诊断出87例亚急性硬化性全脑炎（SSPE）。对于1990年，研究省份中SSPE的年发病率经计算为每百万20岁以下人群中有56例，预计1991年这一数字会更高。发病的平均年龄为4.9岁，男女比例为1.8:1。SSPE患者脑脊液中免疫球蛋白G占总蛋白的百分比升高，脑脊液与血清免疫球蛋白G的比例也增加。PNG地区该病显著的临床表现和高发病率可能与该国儿童麻疹感染年龄较早有关。
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