Rittner C, Meier E M, Stradmann B, Giles C M, Köchling R, Mollenhauer E, Kreth H W
Immunogenetics. 1984;20(4):407-15. doi: 10.1007/BF00345615.
In an immunogenetic study, 23 subacute sclerosing panencephalitis (SSPE) patients and their families were studied for the HLA region markers HLA-A, B, C, DR, BF, C2, C4A, C4B, GLO I, and PGM3. In addition, C3, C4, and factor B serum levels were determined. A highly significant association of C4A QO with SSPE was found. Furthermore, two rare haplotypes, C4A QOB QO, two C4ACh+ allotypes, and four Ch partial inhibitors were detected, which possibly impair the function of the C4 molecules. HLA-DR5 was increased. In addition, a number of rare HLA-A, C, B, DR haplotypes were observed. It is postulated that rare C4 molecular deficiency might be a predisposing factor in the pathogenesis of SSPE.
在一项免疫遗传学研究中，对23例亚急性硬化性全脑炎（SSPE）患者及其家属进行了HLA区域标记物HLA - A、B、C、DR、BF、C2、C4A、C4B、GLO I和PGM3的研究。此外，还测定了C3、C4和B因子的血清水平。发现C4A QO与SSPE有高度显著的关联。此外，检测到两种罕见的单倍型C4A QOB QO、两种C4ACh + 同种异型以及四种Ch部分抑制剂，它们可能会损害C4分子的功能。HLA - DR5有所增加。此外，还观察到一些罕见的HLA - A、C、B、DR单倍型。据推测，罕见的C4分子缺陷可能是SSPE发病机制中的一个易感因素。
