Zilber N, Rannon L, Alter M, Kahana E
Neurology. 1983 Dec;33(12):1558-64.
Between the years 1968 and 1979, 87 cases of subacute sclerosing panencephalitis (SSPE) appeared among the Israeli-born population. The incidence of SSPE dropped sharply in 1977, 10 years (the median age at onset of SSPE) after introduction of mass antimeasles vaccination, and remained low in 1978 and 1979. Most of the SSPE cases reported measles at an age significantly younger than that of the general population. This pattern did not change after introduction of antimeasles vaccination. Incidence was significantly lower (p less than 10(-9) in the vaccinated population than in the unvaccinated population. Occurrence of SSPE in some children who were vaccinated against measles could be explained by incomplete vaccine efficacy, or by older age at vaccination, which allows the possibility of prior exposure to measles. There was no indication that measles vaccine can induce SSPE.
1968年至1979年间，以色列出生人口中出现了87例亚急性硬化性全脑炎（SSPE）。1977年，在大规模接种麻疹疫苗10年后（SSPE发病的中位年龄），SSPE的发病率急剧下降，并在1978年和1979年保持在低水平。大多数SSPE病例报告患麻疹的年龄明显低于普通人群。引入抗麻疹疫苗后，这种模式没有改变。接种疫苗人群的发病率显著低于未接种疫苗人群（p小于10^(-9)）。一些接种过麻疹疫苗的儿童出现SSPE，可能是由于疫苗效力不完全，或者是接种时年龄较大，从而有可能先前接触过麻疹。没有迹象表明麻疹疫苗会诱发SSPE。
