[不同厂家复方丹参片紫外吸收光谱的相关性分析]

[A correlate analysis of UV absorption spectra of compound danshen tablets from different manufactures].

作者信息

Mo Zhi-jiang, Zhang Li-juan

机构信息

The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2005 Apr;30(7):507-10.

PMID:16011093

Abstract

OBJECTIVE

To evaluate the value of UV absorption spectrum for identification and quality control of compound Danshen tablets and pills.

METHOD

UV absorption spectra of compound Danshen tablets and pills, and other drugs were scanned using ultraviolet spectrophotometer (water as the solvent). Pearson's correlation coefficients (Pearson's R) were displayed in the correlations table obtained from SPSS correlate, and deltaR defined as the absolute value of the difference between Pearson's R and its mirror image in the table were used for measuring the spectral similarity between two drugs from different manufacturers.

RESULT

Regarding compound Danshen tablets and pills, the spectral similarity between different batch drugs from same manufacturer was very high with Pearson's R = 0.995-0.9999, and the similarity between two manufactures was high with Pearson's R = 0.92-0.997 and deltaR < 0.02. Compared with the spectra of compound Danshen tablets and pills, the spectral similarity of the other drugs was low with Pearson's R = 0.25-0.98 and deltaR > 0.02.

CONCLUSION

The results showed that UV absorption spectrum could be suitable for identification and quality control of compound Danshen tablets and pills.

摘要

目的

评估紫外吸收光谱在复方丹参片和滴丸鉴别及质量控制中的价值。

方法

采用紫外分光光度计（以水为溶剂）扫描复方丹参片和滴丸以及其他药物的紫外吸收光谱。从SPSS相关性分析得到的相关性表中显示皮尔逊相关系数（Pearson's R），用Pearson's R与其在表中的镜像之差的绝对值即deltaR来衡量不同厂家两种药物之间的光谱相似度。

结果

对于复方丹参片和滴丸，同一厂家不同批次药物之间的光谱相似度非常高，Pearson's R = 0.995 - 0.9999，两个厂家之间的相似度较高，Pearson's R = 0.92 - 0.997且deltaR < 0.02。与复方丹参片和滴丸的光谱相比，其他药物的光谱相似度较低，Pearson's R = 0.25 - 0.98且deltaR > 0.02。