复方丹参缓释片水溶性成分释放的研究
[Study on the water-soluble composition release of compound Danshen sustained-release tablet].
作者信息
Zhu Shen-shang, Yuan Xu-jiang, Li Yuan-xin
机构信息
Guangdong College of Pharmacy, Guangzhou, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2006 Jan;31(1):37-40.
OBJECTIVE
To study on the release of compound Danshen sustained-release tablet and the evaluate method of Chinese material medica compound sustained-release preparation.
METHOD
Rotating basket method and HPLC were employed.
RESULT
Through the determination of 6 time-point samples, the water-soluble compositions of compound Danshen sustained-release tablet had a Well-balanced release behavior with a zero-grade release model or Higuchi release model.
CONCLUSION
Compound Danshen sustained-release tablet had a zero-grade release model. The method was rapid and stable and could be applied to evaluate the water-soluble composition release of compound Danshen sustained-release Tablet.
目的
研究复方丹参缓释片的释放度及中药复方缓释制剂的评价方法。
方法
采用转篮法和高效液相色谱法。
结果
通过对6个时间点样品的测定，复方丹参缓释片的水溶性成分具有良好的释放行为，符合零级释放模型或Higuchi释放模型。
结论
复方丹参缓释片具有零级释放模型。该方法快速、稳定，可用于评价复方丹参缓释片水溶性成分的释放度。
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