Evans David A, Seidel Daniel
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
J Am Chem Soc. 2005 Jul 20;127(28):9958-9. doi: 10.1021/ja052935r.
A highly enantioselective Michael addition of 1,3-dicarbonyl compounds to nitroalkenes has been developed that employs a newly developed Ni(II)-(bis)diamine based catalyst. The reaction scope includes substituted and unsubstituted malonates, beta-ketoesters, and nitroalkenes bearing aromatic and aliphatic residues. Ease of synthesis of this complex is noteworthy.
已开发出一种1,3 - 二羰基化合物与硝基烯烃的高度对映选择性迈克尔加成反应，该反应采用了新开发的基于镍（II）-（双）二胺的催化剂。反应范围包括取代和未取代的丙二酸酯、β-酮酯以及带有芳香族和脂肪族残基的硝基烯烃。值得注意的是这种配合物易于合成。
