Severe CNS side-effect and persistent high efavirenz plasma levels in a patient with HIV/HCV coinfection and liver cirrhosis.
作者信息
Bickel Markus, Stephan Christoph, Rottmann Carsten, Carlebach Amina, Haberl Anette, Kurowski Michael, Staszewski Schlomo
机构信息
HIV Treatment and Research Unit, JW Goethe University, Frankfurt, Germany.
出版信息
Scand J Infect Dis. 2005;37(6-7):520-2. doi: 10.1080/00365540410020901.
PMID:16012018
Abstract
We describe an HIV/HCV coinfected patient with liver cirrhosis, who experienced severe CNS side-effects during efavirenz-based HIV therapy. Plasma levels of efavirenz were 10 times the upper limit and remained elevated (at twice the upper limit) 4 weeks after cessation of therapy. Efavirenz resistance (K103N) developed and was probably due to 'functional' monotherapy.
摘要
Zotero 插件