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三刺鱼（Gasterosteus aculeatus）肾脏中雄烯二酮和11-酮睾酮的代谢

Metabolism of androstenedione and 11-ketotestosterone in the kidney of the three-spined stickleback, Gasterosteus aculeatus.

作者信息

Borg B, Mayer I, Lambert J, Granneman J, Schulz R

机构信息

Department of Zoology, University of Stockholm, Sweden.

出版信息

Gen Comp Endocrinol. 1992 May;86(2):248-56. doi: 10.1016/0016-6480(92)90108-v.

DOI:10.1016/0016-6480(92)90108-v
PMID:1601274
Abstract

Stickleback kidneys were incubated with tritiated androstenedione (A4) or 11-ketotestosterone (OT). After the A4 incubations the following steroids were found, testosterone (T), 5 beta-androstane-3,17-dione (5 beta Ad), etiocholanolone (Et), 5 beta-dihydrotestosterone (5 beta DHT), 5 beta-androstane-3 alpha,17 beta-diol (5 beta A3 alpha 17 beta diol), androsterone, 5 alpha-androstane-3,17-dione, 5 alpha-androstane-3 alpha,17 beta-diol (5 alpha A3 alpha 17 beta diol), as well as glucuronides of T, Et, 5 beta DHT, 5 beta A3 alpha 17 beta diol, and 5 alpha A3 alpha 17 beta diol. The metabolites found in the largest amounts were usually T, 5 beta Ad, Et, and the glucuronides of T, Et, and especially of 5 beta A3 alpha 17 beta diol. These results suggest the main pathway to be A4-5 beta Ad-Et-5 beta A3 alpha 17 beta diol-5 beta A3 alpha 17 beta diol-glucuronide or Et-Et-glucuronide-5 beta A3 alpha 17 beta diol-glucuronide. The formation of 5 beta-reduced compounds was larger in postbreeding males and females than in breeding males. The opposite was the case for 5 alpha-reduced compounds. The total formation of glucuronides was lower in the breeding males than in the other groups. After the OT incubations 11-ketoandrostenedione, 17 beta-hydroxy-5 beta-androstane-3,11-dione (tentatively identified), and OT-glucuronide were found. 17 beta-Hydroxy-5 alpha-androstane-3,11-dione was not present.

摘要

将刺鱼的肾脏与氚标记的雄烯二酮（A4）或11 - 酮睾酮（OT）一起孵育。在A4孵育后，发现了以下类固醇：睾酮（T）、5β - 雄甾烷 - 3,17 - 二酮（5β Ad）、本胆烷醇酮（Et）、5β - 双氢睾酮（5β DHT）、5β - 雄甾烷 - 3α,17β - 二醇（5β A3α17β二醇）、雄酮、5α - 雄甾烷 - 3,17 - 二酮、5α - 雄甾烷 - 3α,17β - 二醇（5α A3α17β二醇），以及T、Et、5β DHT、5β A3α17β二醇和5α A3α17β二醇的葡萄糖醛酸苷。含量最多的代谢产物通常是T、5β Ad、Et，以及T、Et尤其是5β A3α17β二醇的葡萄糖醛酸苷。这些结果表明主要途径是A4 - 5β Ad - Et - 5β A3α17β二醇 - 5β A3α17β二醇 - 葡萄糖醛酸苷或Et - Et - 葡萄糖醛酸苷 - 5β A3α17β二醇 - 葡萄糖醛酸苷。繁殖后的雄性和雌性中5β - 还原化合物的形成比繁殖期雄性更多。5α - 还原化合物的情况则相反。繁殖期雄性中葡萄糖醛酸苷的总形成量低于其他组。在OT孵育后，发现了11 - 酮雄烯二酮、17β - 羟基 - 5β - 雄甾烷 - 3,11 - 二酮（初步鉴定）和OT - 葡萄糖醛酸苷。未发现17β - 羟基 - 5α - 雄甾烷 - 3,11 - 二酮。

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