虹鳟（Oncorhynchus mykiss）皮肤中的雄激素代谢。
Androgen metabolism in the skin of the rainbow trout (Oncorhynchus mykiss).
机构信息
Institut für Zoologie, University of Mainz, D-6500, Mainz, Germany.
出版信息
Fish Physiol Biochem. 1993 Jul;11(1-6):281-6. doi: 10.1007/BF00004576.
Pieces of skin of male and female rainbow trout (Oncorhynchus mykiss) were incubated with testosterone and 11-ketotestosterone as substrates. In immature fish the conversion rate was low. In non-spawning adult males 11-ketotestosterone was reduced to 5α-11KDHT (up to 5.2%). In the fish in spawning condition the 5α-reduction rate was only about 1 to 2%. In the same specimens incubated with testosterone a high 11β-hydroxylase activity (23.8-25% in the male and 13% in the female skin) was found. Similar sex specific differences were observed for the occurence of 5α-reduced metabolites (about 20% in the male and 13% in the female tissue).
雄性和雌性虹鳟（Oncorhynchus mykiss）的皮肤碎片与睾酮和 11-酮睾酮一起孵育。在未成熟的鱼中，转化率很低。在非繁殖期的成年雄性中，11-酮睾酮被还原为 5α-11KDHT（高达 5.2%）。在处于繁殖状态的鱼中，5α-还原率仅约为 1%至 2%。在用睾酮孵育的相同标本中，发现了高 11β-羟化酶活性（雄性为 23.8-25%，雌性为 13%）。在 5α-还原代谢物的发生中也观察到类似的性别特异性差异（雄性约为 20%，雌性为 13%）。
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