Yoshida Kenichi
Department of Life Sciences, Meiji University, 1-1-1 Higashimita, Kawasaki, Kanagawa 214-8571, Japan.
Int J Mol Med. 2005 Aug;16(2):343-7.
The ASBs are a family of ankyrin-repeat proteins that contain a C-terminal SOCS box motif, which was first identified in the suppressor of cytokine signaling (SOCS) proteins. Here, we identified the ASB15 gene by using bio-informatics. Human ASB15 gene, consisting of 12 exons, was located within human genome sequences RP11-390E23 (AC006333.3). Complete coding sequence of human ASB15 cDNA was determined by FLJ43370 cDNA (AK125360), which was identified by using partial coding sequence of human ASB15 cDNA (AF403033) as a query. Human, chimpanzee, bovine, canine, and murine ASB15 showed 88-99% total-amino acid identity. N-terminal and central seven ankyrin repeats, and C-terminal SOCS box were identified within ASB15 protein.
锚蛋白重复序列结合蛋白（ASB）是一个包含C末端细胞因子信号抑制因子（SOCS）盒基序的锚蛋白重复序列蛋白家族，该基序最初是在细胞因子信号抑制因子（SOCS）蛋白中发现的。在此，我们通过生物信息学方法鉴定了ASB15基因。人类ASB15基因由12个外显子组成，位于人类基因组序列RP11 - 390E23（AC006333.3）内。人类ASB15 cDNA的完整编码序列由FLJ43370 cDNA（AK125360）确定，该cDNA是通过使用人类ASB15 cDNA（AF403033）的部分编码序列作为查询序列而鉴定出来的。人类、黑猩猩、牛、犬和小鼠的ASB15在总氨基酸水平上显示出88% - 99%的同一性。在ASB15蛋白中鉴定出了N末端和中央的七个锚蛋白重复序列以及C末端的SOCS盒。
