Friedman Avner, Craciun Gheorghe
Mathematical Biosciences Institute, The Ohio State University, 231 W 18th Avenue, Columbus, OH 43210, USA.
J Math Biol. 2005 Aug;51(2):217-46. doi: 10.1007/s00285-004-0285-3. Epub 2005 Jul 13.
In this paper we develop a model of intracellular transport of cell organelles and vesicles along the axon of a nerve cell. These particles are moving alternately by processive motion along a microtubule with the aid of motor proteins, and by diffusion. The model involves a degenerate system of diffusion equations. We prove a maximum principle and establish existence and behavior of a unique solution. Numerical results show how the transportation of mass depends on the relevant parameters of the model.
在本文中,我们建立了一个关于细胞器和囊泡沿神经细胞轴突进行细胞内运输的模型。这些颗粒借助运动蛋白沿着微管通过连续运动交替移动,并通过扩散移动。该模型涉及一个退化的扩散方程组。我们证明了一个最大值原理,并建立了唯一解的存在性和性质。数值结果表明了物质运输如何依赖于模型的相关参数。