Blum J J, Reed M C
Department of Physiology, Duke University, Durham, North Carolina.
Cell Motil Cytoskeleton. 1989;12(1):53-65. doi: 10.1002/cm.970120107.
A model for slow axonal transport is developed in which the essential features are reversible binding of cytoskeletal elements and of soluble cytosolic proteins to each other and to motile elements such as actin microfilaments. Computer simulation of the equations of the model demonstrate that the model can account for many of the features of the SCa and SCb waves observed in pulse experiments. The model also provides a unified explanation for the increase and decrease of neurofilament transport rates observed in various toxicant-induced neuropathies.
建立了一个慢轴突运输模型，其基本特征是细胞骨架成分与可溶性胞质蛋白之间以及它们与诸如肌动蛋白微丝等运动元件之间的可逆结合。对该模型方程的计算机模拟表明，该模型可以解释脉冲实验中观察到的SCa和SCb波的许多特征。该模型还为在各种毒物诱导的神经病变中观察到的神经丝运输速率的增加和减少提供了统一的解释。
