在来自中西部非洲的12名半免疫成年人中，使用磺胺多辛/乙胺嘧啶联合疗法治疗疟疾，这些成年人的恶性疟原虫二氢叶酸还原酶（dhfr）和二氢蝶酸合成酶（dhps）基因点突变率很高。
Malaria cure with sulphadoxine/pyrimethamine combination in 12 semi-immune adults from West-Central Africa with high rates of point mutations in Plasmodium falciparum dhfr and dhps genes.
作者信息
Berzosa Pedro J, Puente Sabino, Benito Agustìn
机构信息
Laboratorio de Malaria, Servicio de Parasitología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra. Majadahonda-Pozuelo Km 2, 28220 Majadahonda, Madrid, Spain.
出版信息
Parasitol Res. 2005 Oct;97(4):287-9. doi: 10.1007/s00436-005-1424-5. Epub 2005 Jul 13.
We report 12 uncomplicated falciparum-malaria cases from semi-immune people from Central Africa treated with sulfadoxine/pyrimethamine (Fansidar) in a Spanish hospital. We resolved by PCR-RFLP the mutations in dhfr and dhps genes related to resistance to antifolate drugs. The 12 patients presented high frequencies of combined mutations in both genes but they were completely cured after treatment.
我们报告了12例来自中非半免疫人群的单纯性恶性疟病例，这些病例在一家西班牙医院接受了磺胺多辛/乙胺嘧啶（Fansidar）治疗。我们通过PCR-RFLP方法解析了与抗叶酸药物耐药性相关的二氢叶酸还原酶（dhfr）和二氢蝶酸合酶（dhps）基因的突变情况。这12例患者在这两个基因中均出现了高频率的联合突变，但治疗后均完全治愈。
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