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惰性气体作为未来的吸入性麻醉剂?

Inert gases as the future inhalational anaesthetics?

作者信息

Preckel Benedikt, Schlack Wolfgang

机构信息

Department of Anaesthesiology, Dusseldorf University Hospital, P.O. Box 10 10 07, D-40001 Düsseldorf, Germany.

出版信息

Best Pract Res Clin Anaesthesiol. 2005 Sep;19(3):365-79. doi: 10.1016/j.bpa.2005.01.002.

Abstract

Of all the inert gases, only xenon has considerable anaesthetic properties under normobaric conditions. Its very low blood/gas partition coefficient makes induction of and emergence from anaesthesia more rapid compared with other inhalational anaesthetics. In experimental and clinical studies the safety and efficiency of xenon as an anaesthetic has been demonstrated. Xenon causes several physiological changes, which mediate protection of the brain or myocardium. The use of xenon might therefore be beneficial in certain clinical situations, as in patients at high risk for neurological or cardiac damage.

摘要

在所有惰性气体中,只有氙气在常压条件下具有可观的麻醉特性。与其他吸入性麻醉剂相比,其极低的血/气分配系数使麻醉诱导和苏醒更快。在实验和临床研究中,氙气作为麻醉剂的安全性和有效性已得到证实。氙气会引起多种生理变化,这些变化介导对大脑或心肌的保护。因此,在某些临床情况下,如对于有神经或心脏损伤高风险的患者,使用氙气可能有益。

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