Youinou Pierre, Jamin Christophe, Pers Jacques-Olivier, Berthou Christian, Saraux Alain, Renaudineau Yves
Laboratory of Immunology, Brest University Medical School Hospital, BP824, F29609 Brest Cedex, France.
Ann N Y Acad Sci. 2005 Jun;1050:19-33. doi: 10.1196/annals.1313.003.
Recent studies have revealed that B cells serve extraordinarily diverse functions within the immune system in addition to antibody production. These functions contribute to autoimmunity. They initiate the development of lymphoid architecture and regulate dendritic and T-cell function through cytokine production. Receptor editing is also essential to prevent autoimmunity. Both abnormalities in the distribution of B-cell subsets and the benefits of ablative B-cell therapy of autoimmune states confirm their importance. Results from transgenic models have demonstrated that the sensitivity of B cells to antigen receptor cross-linking correlates to autoimmunity, with particular reference to negative signaling by CD5 and CD22. These mechanisms maintain tolerance by recruiting src-homology 2 domain-containing protein tyrosine phosphatase-1. These findings open new prospects for immunotherapy of autoimmune diseases.
最近的研究表明，B细胞除了产生抗体外，在免疫系统中还发挥着极其多样的功能。这些功能会导致自身免疫。它们启动淋巴组织结构的发育，并通过产生细胞因子来调节树突状细胞和T细胞的功能。受体编辑对于预防自身免疫也至关重要。B细胞亚群分布的异常以及自身免疫状态下B细胞清除疗法的益处都证实了它们的重要性。转基因模型的结果表明，B细胞对抗抗原受体交联的敏感性与自身免疫相关，特别是涉及CD5和CD22的负向信号传导。这些机制通过招募含src同源2结构域的蛋白酪氨酸磷酸酶-1来维持耐受性。这些发现为自身免疫性疾病的免疫治疗开辟了新的前景。
