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原发性干燥综合征中的自身免疫与柯萨奇病毒感染

Autoimmunity and coxsackievirus infection in primary Sjogren's syndrome.

作者信息

Triantafyllopoulou Antigoni, Moutsopoulos Haralampos M

机构信息

Department of Pathophysiology, National University of Athens Medical School, M. Asias 75, Goudi, Athens 11527, Greece.

出版信息

Ann N Y Acad Sci. 2005 Jun;1050:389-96. doi: 10.1196/annals.1313.090.

DOI:10.1196/annals.1313.090
PMID:16014556
Abstract

Exocrine gland epithelial cells are the target of autoimmune pathology in primary Sjögren's syndrome (pSS). Their activated phenotype has incited the notion that they are infected by a virus. We recently presented evidence that coxsackieviruses may persistently infect the salivary glands of pSS patients. We hypothesize that coxsackieviruses may play a permissive role for the perpetuation and possibly the induction of autoimmune disease in pSS.

摘要

外分泌腺上皮细胞是原发性干燥综合征（pSS）自身免疫病理的靶细胞。它们的活化表型引发了它们被病毒感染的观点。我们最近提出证据表明，柯萨奇病毒可能持续感染pSS患者的唾液腺。我们推测，柯萨奇病毒可能在pSS自身免疫疾病的持续存在甚至可能诱导过程中发挥许可作用。

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