Natarajan M, Mukundan P, John T J
Department of Virology & Immunology, Christian Medical College & Hospital, Vellore.
Indian J Med Res. 1992 Mar;95:51-3.
The immunogenic efficacy of the first batch of indigenous purified chick embryo cell culture grown (PCEC) rabies virus vaccine has been measured in ten subjects. All of them were immunologically naive to rabies virus, and were given 5 doses of the vaccine in the post-exposure regime of injections on days 0, 3, 7, 14 and 30. On day 7, four subjects had developed very low levels of rabies virus neutralizing antibody, as detected and measured in the suckling mouse neutralization test. On day 14, all subjects had protective levels of antibody, which were maintained or enhanced by day 30. With the limited data presented here, the immunogenic efficacy of this batch of vaccine appeared similar to that of a batch of imported PCEC vaccine investigated earlier.
已对10名受试者测量了首批国产纯化鸡胚细胞培养狂犬病病毒疫苗的免疫原性效力。他们均对狂犬病病毒无免疫史，在暴露后方案中于第0、3、7、14和30天接种5剂疫苗。在第7天，通过乳鼠中和试验检测和测量发现，4名受试者产生了极低水平的狂犬病病毒中和抗体。在第14天，所有受试者的抗体水平均达到保护水平，并在第30天维持或升高。根据此处提供的有限数据，这批疫苗的免疫原性效力似乎与早前研究的一批进口纯化鸡胚细胞培养疫苗相似。
