Eisele Thomas P, Lindblade Kim A, Wannemuehler Kathleen A, Gimnig John E, Odhiambo Frank, Hawley William A, Ter Kuile Feiko O, Phillips-Howard Penny, Rosen Daniel H, Nahlen Bernard L, Vulule John M, Slutsker Laurence
Department of International Heath and Development, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA.
Am J Trop Med Hyg. 2005 Jul;73(1):149-56.
We present results from a study conducted in western Kenya where all-cause child mortality was assessed among a population with high levels of sustained insecticide-treated bed net (ITN) use for up to six years. Although ITNs were associated with significant reductions in all-cause mortality among infants 1-11 months old, there was no difference in the rate of all-cause mortality among children 12-59 months old with ITNs for 2-4 years, compared historically with children from villages without ITNs, after controlling for seasonality and underlying child mortality across calendar years (adjusted hazard ratio [AHR] = 0.91, 95% confidence interval [CI] = 0.77-1.07). There was no increase in the proportion of child deaths at older ages (12-59 months old) of all child deaths within villages with ITNs for 5-6 years (48.1%) compared historically with villages without ITNs (47.9%), after controlling for seasonality (AHR = 1.03, P = 0.834). We find no evidence that sustained ITN use increased the risk of mortality in older children in this area of intense perennial malaria transmission.
我们展示了在肯尼亚西部进行的一项研究结果，该研究评估了在长达六年的时间里持续大量使用长效驱虫蚊帐（ITN）的人群中的全因儿童死亡率。尽管ITN与1至11个月大婴儿的全因死亡率显著降低相关，但在控制了季节性和历年潜在儿童死亡率后，与历史上没有ITN的村庄的儿童相比，使用ITN 2至4年的12至59个月大儿童的全因死亡率没有差异（调整后风险比[AHR]=0.91，95%置信区间[CI]=0.77-1.07）。在控制季节性后，与历史上没有ITN的村庄（47.9%）相比，使用ITN 5至6年的村庄中，12至59个月大儿童死亡占所有儿童死亡的比例没有增加（48.1%）（AHR=1.03，P=0.834）。我们没有发现证据表明在这个常年疟疾传播强烈的地区，持续使用ITN会增加大龄儿童的死亡风险。
