Bevins Charles L
Dept. of Medical Microbiology and Immunology, University of California School of Medicine, One Shields Ave., Tupper Hall Rm. 3146, Davis, CA 95616, USA.
Am J Physiol Gastrointest Liver Physiol. 2005 Aug;289(2):G173-6. doi: 10.1152/ajpgi.00079.2005.
Host defense of the small intestine is mediated, in part, by antimicrobial peptides, including alpha-defensins. In the small intestine, Paneth cells, specialized secretory epithelial cells located at the base of the crypt invaginations lining the intestinal wall, produce alpha-defensins. The alpha-defensins are cysteine-rich cationic peptides with antibiotic activity against a wide range of bacteria and other microbes. Studies of transgenic and knockout mice have supported a pivotal role of Paneth cell alpha-defensins in protection from bacterial pathogens. New data suggest that deficient expression of Paneth cell alpha-defensins may contribute to the pathophysiology of Crohn's disease, a chronic inflammatory bowel disease.
小肠的宿主防御部分由抗菌肽介导，包括α-防御素。在小肠中，潘氏细胞是位于肠壁隐窝内衬底部的特殊分泌上皮细胞，可产生α-防御素。α-防御素是富含半胱氨酸的阳离子肽，对多种细菌和其他微生物具有抗菌活性。对转基因小鼠和基因敲除小鼠的研究支持了潘氏细胞α-防御素在抵御细菌病原体方面的关键作用。新数据表明，潘氏细胞α-防御素表达不足可能与克罗恩病（一种慢性炎症性肠病）的病理生理学有关。
