肠道守护者：肠道防御素
Guardians of the Gut: Enteric Defensins.
作者信息
Sankaran-Walters Sumathi, Hart Ronald, Dills Chantelle
机构信息
Medical Microbiology and Immunology, University of California, DavisDavis, CA, USA.
出版信息
Front Microbiol. 2017 Apr 19;8:647. doi: 10.3389/fmicb.2017.00647. eCollection 2017.
Abstract
Enteric defensins likely play a key role in the management of the human microbiome throughout development. The functional and mechanistic diversity of defensins is much greater than was initially thought. Defensin expression and overall Paneth cell physiology likely plays a key role in the development of colitis and other inflammatory or dysbiotic diseases of the gut. As our understanding of enteric defensins grows, their potential as tools of clinical intervention becomes more apparent. In this review, we focus on the function and activity of Paneth Cell defensins and highlight their role in disease.
摘要
肠道防御素可能在人类微生物群的整个发育过程管理中发挥关键作用。防御素的功能和机制多样性比最初认为的要大得多。防御素的表达和潘氏细胞的整体生理功能可能在结肠炎和其他肠道炎症或生态失调疾病的发展中起关键作用。随着我们对肠道防御素认识的不断加深，它们作为临床干预工具的潜力变得更加明显。在这篇综述中，我们重点关注潘氏细胞防御素的功能和活性，并强调它们在疾病中的作用。
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