多次输血的地中海贫血患儿对乙型肝炎病毒感染的血清学反应

Serological responses to hepatitis B virus infection in multi-transfused thalassemic children.

作者信息

Gulati S, Marwaha R K, Dilawari J B, Midha U, Walia B N

机构信息

Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh.

出版信息

Indian Pediatr. 1992 Jan;29(1):73-7.

PMID:1601501

Abstract

One hundred children with beta-thalassemia major were studied prospectively. A one time analysis of serum samples was carried out for a battery of hepatitis B viral markers viz., HBsAg, anti-HBs and anti-HBc. Seven mutually different serological patterns were observed. The commonest profile seen in 49 patients was a combined seropositivity for anti-HBc and anti-HBs indicating past HBV infection with persisting immunity. Definite evidence of active HBV infection (seropositivity for HBsAg and/or HBeAg) was demonstrated in 10 cases, six of these were HBsAg positive. Anti-HBc positivity alone was detected in 17 patients. The remaining 24 children were seropositive for anti-HBs alone suggesting a possible passive transmission of anti-HBs through blood transfusion.

摘要

对100名重型β地中海贫血患儿进行了前瞻性研究。对一组乙肝病毒标志物，即乙肝表面抗原（HBsAg）、乙肝表面抗体（抗-HBs）和乙肝核心抗体（抗-HBc）进行了血清样本的一次性分析。观察到七种互不相同的血清学模式。49例患者中最常见的情况是抗-HBc和抗-HBs联合血清阳性，表明既往感染过乙肝病毒且仍有免疫力。10例患者有活动性乙肝病毒感染的确切证据（HBsAg和/或HBeAg血清阳性），其中6例HBsAg阳性。17例患者仅抗-HBc阳性。其余24名儿童仅抗-HBs血清阳性，提示抗-HBs可能通过输血被动传播。