Hoffman Richard S, Fine I Howard, Packer Mark, Reynolds Tony P, Bebber Cherie Van
Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA.
Cornea. 2005 Aug;24(6):699-704. doi: 10.1097/01.ico.0000154379.75119.ba.
To demonstrate a potential cause of a prolonged epidemic of diffuse lamellar keratitis (DLK).
This retrospective review analyzed an epidemic of diffuse lamellar keratitis over a 3-year period in a single surgery center. Altering the brand of surgical gloves used during surgery was associated with an elimination of the DLK epidemic. Optical microscopy, scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS), and Fourier transform infrared (FTIR) spectroscopy were performed on both brands of surgical gloves to allow for comparisons and determine possible surface contaminants responsible for the DLK outbreaks.
The incidence of DLK during the epidemic ranged from 2% to 38% on a quarterly basis for the 3-year period. A change in the brand of surgical gloves resulted in a cessation of DLK. Surface analysis of both brands of gloves revealed extensive silicone oil contamination on the internal and external surfaces of the DLK-associated gloves and insignificant amounts of silicone oil on the external surface of the DLK-free gloves.
Silicone oil contamination of surgical gloves appears to be associated with epidemic DLK.
证明弥漫性层间角膜炎（DLK）长期流行的一个潜在原因。
这项回顾性研究分析了单个手术中心3年内弥漫性层间角膜炎的一次流行情况。手术中使用的手术手套品牌的改变与DLK流行的消除相关。对两种品牌的手术手套进行了光学显微镜检查、扫描电子显微镜 - 能量色散光谱分析（SEM - EDS）和傅里叶变换红外（FTIR）光谱分析，以便进行比较并确定可能导致DLK暴发的表面污染物。
在这3年期间，DLK的发病率按季度计算在2%至38%之间。手术手套品牌的改变导致DLK停止。对两种品牌手套的表面分析显示，与DLK相关的手套内外表面存在大量硅油污染，而无DLK的手套外表面硅油含量极少。
手术手套的硅油污染似乎与DLK流行有关。
