Hwu Jinn-Jong, Chen Ko-Hua, Hsu Wen-Ming, Lai Jui-Yang, Li Yen-Shien
Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Cornea. 2005 Aug;24(6):754-6. doi: 10.1097/01.ico.0000154386.43732.b5.
To report a case of ocular allergy to topical vancomycin eye drops.
Interventional case report.
A 76-year-old man presented with progressive itching, soreness, and burning sensations, photophobia, and tearing in his left eye 3 days after completing 2 weeks of treatment with 5% vancomycin eye drops. He had been suffering for the previous 2 years from chronic recurrent endophthalmitis and secondary glaucoma associated with cataract surgery in his left eye. He denied any history of drug or food allergy. Examination by slit-lamp microscope showed left periorbital skin erosive rash, marked hyperemia of conjunctiva, central epithelial defect, corneal stromal edema, and Descemet membrane striae. Vancomycin skin tests were positive. The patient's symptoms resolved after discontinuing vancomycin eye drops and responded well to systemic corticosteroids, antihistamines, and topical corticosteroid treatments. Teicoplanin treated his endophthalmitis successfully.
A case of hypersensitivity to topical vancamycin was reported. Patients who receive topical vancomycin should be informed of this possible adverse effect and instructed to contact their ophthalmologists if allergic reactions occur.
报告1例对局部用万古霉素滴眼液发生眼部过敏的病例。
介入性病例报告。
一名76岁男性在使用5%万古霉素滴眼液治疗2周结束后3天，左眼出现进行性瘙痒、酸痛、烧灼感、畏光及流泪症状。他在过去2年一直患有左眼慢性复发性眼内炎及与白内障手术相关的继发性青光眼。他否认有任何药物或食物过敏史。裂隙灯显微镜检查显示左眼眶周皮肤糜烂性皮疹、结膜明显充血、中央上皮缺损、角膜基质水肿及后弹力层皱折。万古霉素皮肤试验呈阳性。停用万古霉素滴眼液后患者症状缓解，并对全身用皮质类固醇、抗组胺药及局部用皮质类固醇治疗反应良好。替考拉宁成功治疗了他的眼内炎。
报告了1例对局部用万古霉素过敏的病例。应告知接受局部用万古霉素治疗的患者可能出现这种不良反应，并指导他们如果发生过敏反应要联系眼科医生。
