Vasků J, Urbánek P, Dostál M, Vasků J
Vacord-Bioengineering Research Company Ltd., Brno, Czechoslovakia.
Int J Artif Organs. 1992 May;15(5):307-11.
Long-term experiments with the total artificial heart (TAH) are a source of valuable knowledge for later clinical application. Our observations result from 66 long-term experiments on calves and one goat ranging from 30 to 314 days, which have shown the main possible complications in the early period (one month) and later in the experiment. Problems until the second month of pumping concern the clinical pendant of the TAH as a bridge for transplantation, i.e. surgical problems, blood coagulation disorders, infection etc. Later problems are high venous pressure or arterial hypertension, infection with septic thromboembolization, mineralization of the driving diaphragm, etc., and are more closely comparable to the conditions of permanent clinical use of the TAH. Faultless surgery, device function and the regimen of pumping are essential factors in every long-term experiment, just as in clinical application. Infection is a threat throughout any experiment, as in clinical cases. The TNS-BRNO-VII/clin/80 TAH has been implanted in six patients.
全人工心脏（TAH）的长期实验是后续临床应用宝贵知识的来源。我们的观察结果来自对66只小牛和1只山羊进行的为期30至314天的长期实验，这些实验展示了早期（一个月）及实验后期主要可能出现的并发症。在泵血的第二个月之前出现的问题涉及TAH作为移植桥梁的临床相关问题，即手术问题、凝血障碍、感染等。后期问题包括高静脉压或动脉高血压、感染伴脓毒性血栓栓塞、驱动隔膜矿化等，并且与TAH长期临床使用的情况更具可比性。完美的手术、设备功能和泵血方案是每项长期实验的关键因素，临床应用亦是如此。与临床病例一样，在任何实验过程中感染都是一种威胁。TNS-BRNO-VII/clin/80型TAH已植入6名患者体内。
